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“Nephron loss in the ageing kidney — it’s more than you think.”

 

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Authors: John F. Bertram and Wendy E. Hoy

Article Nephron loss in the ageing kidney John Bertram & Wendy Hoy

Nephron number varies widely in healthy adults. The extent to which this variation is due to differences in nephron endowment at birth and/or nephron loss with ageing is unclear. A recent study used a novel approach to identify a previously unappreciated high loss of nephrons with ageing in healthy kidneys.

John F. Bertram is at the Cardiovascular Program, Monash Biomedicine Discovery Institute, and
Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

Wendy E. Hoy is at the Centre for Research Excellence in Chronic Kidney Disease, at the School of Medicine, University of Queensland, Queensland, Australia.

Correspondence: to J.F.B. @ john.bertram@monash.edu